After the oncogenic protein is transferred, the recipient cells become transformed and show characteristic changes in the expression levels of target genes.
An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
Furthermore, mass spectrometry may be used to determine if a protein has high expression levels that do not correlate to the enzyme's measured metabolic activity.
By leaving existing telomeric and sub-telomeric sequences, they were able to amplify expression levels of genes coding for erythropoietin production over 1000-fold.