Balanced translocations usually do not cause any health problems in the carrier; however, they can become unbalanced as they are passed to the next generation.
The balanced translocation figure shows a 14/21 translocation between the long arms of chromosomes 14 and 21, where the other chromosomes are not shown.
The remaining 10-15% are due to unequal segregation of a parental balanced translocation where the 5p monosomy is often accompanied by a trisomic portion of the genome.