Evidence suggests that failure of defenses against oxidative stress up-regulates programmed cell death (apoptosis), among many other possible consequences.
Cell death may be instigated in the meibomian glands, hypothalamic cells, hippocampus cells andimportant for treatment of acnein sebaceous gland cells.
Second, the polymers themselves clog up the endoplasmic reticulum of cells that synthesize serpins, eventually resulting in cell death and tissue damage.
