Like the other triptans sumatriptan and zolmitriptan, rizatriptan induces vasoconstrictionpossibly by inhibiting the release of calcitonin gene-related peptide from sensory neurons in the trigeminal nerve.
It passes through the ring of the stapes and divides into supraorbital, infraorbital, and mandibular branches which follow the three divisions of the trigeminal nerve.
In addition to treating certain types of cancer, the center also treats trigeminal neuralgia, a neuropathic disorder that causes intense pain throughout the face.