The term high throughput tools in nutrigenomics refers to genetic tools that enable millions of genetic screening tests to be conducted at a single time.
Questions within physiology, ecology, evolution, and many other fields can be investigated using ionomics, often coupled with bioinformatics and other genetic tools.
Much cheaper than conducting human studies and more flexible due to the availability of genetic tools, mouse studies are often used to test scientific ideas.
After all, we have already altered many species profoundly, and it is hard to see how a careful application of genetic tools are fundamentally different.