Direct intrahypothalamic administration of the drugs (16 micrograms procaine/animal) induces a pattern of responses which is generally opposite to that observed for intravenous injection.
The search for a less toxic and less addictive substitute led to the development of the aminoester local anesthetics stovaine in 1903 and procaine in 1904.
The cosmetics do not have anything to do with the procaine drugs, are made of natural plant extracts, produced to high quality standards and are generally approved.
They set about comparing inflammatory responses following surgery in horses administered a mixture of procaine and penicillin and those not administered the medication.
