He is notable for his theoretical contributions to sociobiology, especial altruism, cooperation, epistemic game theory, gene-culture coevolution, efficiency wages, strong reciprocity, and human capital theory.
The books strongly polarised the scientific community, and one reviewer described his ideas of sociobiology as extreme and giving a dismal, unappealing view of humanity.
Furthermore, a significant number of biologists argued that sociobiology does not necessarily lead to any particular political ideology as many critics implied.