Deficient biotinidase activity causes specific metabolic enzymes, called carboxylases, to be nonfunctional, inhibiting the proper processing of proteins, fats, and carbohydrates.
They suffered for decades from inadequate funding, outmoded or dilapidated facilities, and deficient textbooks (often ones previously used in white schools).
Evidence that nodal signaling is responsible for left-right specification comes from genetic analysis of organisms deficient in left-right specification.
Applications of pure perfluorocarbon liquid breathing (which uses pure perfluorocarbon liquid, not a water emulsion) include assisting burn victims and premature babies with deficient lungs.