This increase in disease severity may be reflected in worsening of a variety of laboratory findings, mainly renal (proteinuria, haematuria, leukocyturia) and haematological (thrombocytopenia and leukopenia) involvement.
Large pelvic tumours causing ureteric and rectal obstruction with gross haematuria or painful bone metastases causing spinal cord compression used to be common presenting symptoms, but are now rarely seen.
