I'm going to bet that had she asked a different group of women they may have balked at the acronym, not because it's offensive so much as laughably, despicably trashy.
The kids in your family will probably get the most laughs, but no matter what your age, you'll leave the theater with a despicably huge smile on your face.
She frowned at the conduct of the politicians across parties, saying they have conducted themselves most despicably and have become agents of darkness and crass manipulation.