I.up [美 əp, 英 ʌp]副up often appears as the second element of certain verb structures in English (back up, pick up, sit up, etc). For translations, see the relevant verb entry (back, pick, sit, etc).
The comedian decides she will gen up on the government, in order to criticise them more effectively, and then pulls off the tricky feat of balancing policy points with punchlines.