Significant research efforts have been focused on elucidating the viral pathogenesis of these animal coronaviruses, especially by virologists interested in veterinary and zoonotic diseases.
The discovery of the abundance of viruses and their overwhelming presence in many ecosystems has led modern virologists to reconsider their role in the biosphere.
The book is widely regarded as an extremely influential work on the subject and is cited as the "bible of virology" by many virologists for whom it is indispensable.