The more reflux provided for a given number of theoretical plates, the better is the column's separation of lower boiling materials from higher boiling materials.
By reflux or aspiration of unwanted secretions from the nasopharynx into the normally sterile middle-ear space, the fluid may then become infected - usually with bacteria.
Inside the column, the downflowing reflux liquid provides cooling and condensation of upflowing vapors thereby increasing the efficacy of the distillation tower.
Such constant quantities include feed input rate, output stream rates, heating and cooling rates, reflux ratio, and temperatures, pressures, and compositions at every point (location).