In 1892, he described a 42-year old man with enlargement of the parotid and lacrimal glands associated with a round-cell infiltrate and acinar atrophy.
Then the hypothalamic parotid hormone releasing factor was partially purified but not completed because of the rejection of a research grant application.
Later, at approximately 10 weeks of prenatal development, these cords are canalized and form ducts, with the largest becoming the parotid duct for the parotid gland.
The histopathology is marked by sheets of large swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei.