Another is the risk of acute renal failure, when patients, who had undergone cardiac surgery were given high doses of horse chestnut extract i.v. for postoperative oedema.
M concentrations of the drug; 1 mg of candicine iodide given i.v. to cats produced the same rise in blood pressure as 0.5 mg nicotine; toxic doses produced respiratory paralysis.
The typical i.v. dose used in humans is 400500 mg, but doses totaling up to 10001200 mg have been administered in a series of smaller half-hourly injections.