One study focused on fibrin-based heart valves to assess structure and mechanical durability on sheep revealed promising potential for patient originated valve replacements.
Bleeding is caused by the generation of fibrinogen degradation products which interfere with regular fibrin polymerization and inhibit platelet aggregation.
In biomedical research, fibrin scaffolds have been used to fill bone cavities, repair neurons, heart valves, vascular grafts and the surface of the eye.