Other names in common use include phosphoketotetrose aldolase, erythrulose-1-phosphate synthetase, erythrose-1-phosphate synthase, and erythrulose-1-phosphate formaldehyde-lyase.
Among them are the dihydrofolate reductase inhibitors such as trimethoprim, pyrimethamine, and methotrexate; the sulfonamides (competitive inhibitors of 4-aminobenzoic acid in the reactions of dihydropteroate synthetase).
The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
Other names in common use include 5-phosphoribosylamine synthetase, ribose 5-phosphate aminotransferase, and ammonia-ribose 5-phosphate aminotransferase.