As the name and the description implies, monosynaptic reflexes depend on a single synaptic connection between an afferent sensory neuron and efferent motor neuron.
He recently characterized a phenomenon described as retrograde sensitization of the primary sensory neuron, which emphasizes the importance of the peripheral component of the inflammatory pain.
The neurotransmitter molecules diffuse across the synaptic cleft to the postsynaptic membrane of the primary sensory neuron, where they elicit an action potential.