Humanized antibodies are almost completely human; only the complementarity determining regions of the variable regions are derived from murine antibodies.
Some of the diseases the house mouse carries can be deadly: for example, leptospirosis, murine typhus, rickettsialpox, tularemia, lymphocytic choriomeningitis and potentially bubonic plague.
Furthermore, the receptor for hyaluronan mediated motility has been reported to mediate migration, transformation, and metastatic spread of murine fibroblasts.
