The demand for plasma has actually fallen considerably in recent years, largely because hemophiliacs now use recombinant (synthetic) clotting products.
Symptomatic carriers of the gene, while not hemophiliacs themselves, can have symptoms of hemophilia including a lower than normal blood clotting factor that can lead to heavy bleeding.
While healthy people have proteins in their blood called clotting factors that act quickly to plug wounds, hemophiliacs lack these proteins, making even minor bleeds difficult to stop.
During the recent years, he has been concentrating his activities primarily towards the academic development of transfusion medicine and to provide free factors to hemophiliacs.