Workers who had been exposed to vapors from toluene and/or xylene for 520 years were given either a standardized milk thistle extract (80% silymarin) or placebo for 30 days.
This enzyme forms part of a bacterial metabolic pathway that oxidatively catabolizes toluene, o-xylene, 3-ethyltoluene, and 1,2,4-trimethylbenzene into intermediates of the citric acid cycle.