Many genetic and chemical tools have been generated that allow long-term cell lineage tracing, bringing insight into the longevity of embryonic stem cells for various tissues.
Taking advantage of genetic lineage tracing and tissue-specific gene knockout technology, researchers found that part of the liver vasculature is derived from the endocardium in the developing heart.
By intersectional lineage tracing technology, researchers pinpointed that endocardium-derived liver vasculature is derived from sinus venosus endocardium, which is also the origin of coronary vessels.