Finally, deallylation as above, yielded the freebase of oseltamivir, which was converted to the desired oseltamivir phosphate by treatment with phosphoric acid.
However, the difference between nicotine gum and tobacco gum is that tobacco gum is made from finely powdered tobacco mixed with a gum base, rather than freebase nicotine.
But with traditional cigarettes and now e-cigarettes, heat creates a freebase form of nicotine that is more addictive -- or what smokers would call more satisfying.
