The original antibacterial sulfonamides (sometimes called sulfa drugs or sulpha drugs) are synthetic antimicrobial agents that contain the sulfonamide group.
Amid improvements in endodontics and medicine, including release of sulfa drugs and antibiotics, a backlash to the orgy of tooth extractions and tonsillectomies ensued.
Although a sulfonamide, acetazolamide is a non-antibiotic and has not been shown to cause life-threatening allergic cross-reactivity in those with a self-reported sulfa allergy.
